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Chemical Structure : WJ-39
CAS No.: 3009908-95-3
Catalog No.: PC-22474Not For Human Use, Lab Use Only.
WJ-39 (Darirestat potassium salt) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
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| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
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| 100 mg | Get quote |
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WJ-39 (Darirestat potassium salt) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
WJ-39 treatment ameliorated streptozotocin- (STZ-) induced renal inflammation in diabetic nephropathy (DN) rats.
WJ-39 suppressed the activation of the nuclear factor-kappa B (NF-κB) pathway and the nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome to reduce the secretion of inflammatory factors.
WJ-39 alleviated inflammation via the Nrf2 pathway in rat mesangial cells cultured under high glucose (HG) conditions.
WJ-39 treatment prevented renal fibrosis by suppressing the TGF-β1/Smad pathway in diabetic nephropathy (DN).
WJ-39 reduced oxidative stress in the kidneys of DN rats by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
WJ-39 ameliorates renal tubular injury in diabetic nephropathy by activating PINK1/Parkin signaling.
| M.Wt | 430.32 | |
| Formula | C19H14Cl2KNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1(4H)-Quinolineacetic acid, 3-[(2,3-dichlorophenyl)methyl]-6-methoxy-4-oxo-, potassium salt (1:1) |
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1. Yang L, et al. Eur J Pharmacol. 2024 Mar 15;967:176376.
2. Zhou X, et al. Oxid Med Cell Longev. 2020 May 30;2020:7950457.
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