Catalog No.: PC-24205Not For Human Use, Lab Use Only.
S07-2010 is a potent, pan aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 0.19, 0.36, 0.47, and 0.73 uM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively.
S07-2010 is a potent, pan aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 0.19, 0.36, 0.47, and 0.73 uM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 exhibits obvious cytotoxicity on MCF-7/DOX and A549/DDP, with IC50 = 127.5 and 5.51 μM, respectively. S07-2010 reverses the resistance of the cancer cells to DDP and inhibited tumor proliferation at low concentrations in A549/DDP cells. S07-2010 combined with chemotherapeutic agents promotes apoptosis of cancer cells.
