| Cat. No. |
Product Name |
Information |
| PC-20625 |
Imirestat
Aldose reductase inhibitor
|
Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively. |
| PC-20086 |
BAY1128688
AKR1C3 inhibitor
|
BAY1128688 (BAY-1128688) is a potent, selective steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 1.4 nM (human AKR1C3). |
| PC-38679 |
Govorestat
Aldose Reductase inhibitor
|
Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo. |
| PC-72285 |
TH-3021
AKR1C3 inhibitor
|
TH-3021 (SN336384) is a potent and specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3) with IC50 of 110 nM in isolated enzyme assays and 18 nM in cellular assays, displays no inhibitory action against AKR1C1/1C2/1C4 (IC50>30 uM). |
| PC-35291 |
AKR1C3 inhibitor KV-37
AKR1C3 inhibitor
|
AKR1C3 inhibitor KV-37 is a potent, isoform selective and metabolically stable inhibitor of Aldo-keto reductase 1C3 (AKR1C3) with IC50 of 66 nM, displays 109-fold selectivity over AKR1C2. |
| PC-62883 |
MK204
AKR1B10 inhibitor
|
MK204 is a potent, selective AKR1B10 inhibitor with IC50 of 80 nM, shows high selective (270-fold) over AKR1B1. |
| PC-62882 |
IDD388
Aldose reductase inhibitor
|
IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM). |
| PC-61992 |
Fidarestat
Aldose reductase inhibitor
|
Fidarestat (SNK860) is a potent, selective aldose reductase inhibitor with IC50 of 26 nM. |
| PC-60998 |
ASP9521
AKR1C3
|
ASP9521(ASP-9521) is a potent, selective, orally bioavailable inhibitor of Aldo-keto reductase 1C3 (17βHSD5, AKR1C3) with IC50 of 11 nM and 49 nM for recombinant human or cynomolgus monkey AKR1C3, respectively. |
| PC-45580 |
Caficrestat
Aldose reductase inhibitor
|
AT-001 (Caficrestat) is a highly potent, selective inhibitor of aldose reductase enzymatic activity with IC50 of 28.9 pM. |
| PC-45922 |
Epalrestat
Aldose reductase inhibitor
|
Epalrestat (ONO-2235) is a noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively. |
| PC-24479 |
RJG-2051
AKR1C3 inhibitor
|
RJG-2051 is a potent, selective and covalent aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with IC50 of 13 nM, shows clear selectivity against AKR1C1 (2350-fold), AKR1C2 (1790-fold), and AKR1C4 (429-fold). |
