Cat. No. |
Product Name |
Information |
PC-20086 |
BAY1128688
AKR1C3 inhibitor
|
BAY1128688 is a potent, steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with potential for endometriosis. |
PC-62882 |
IDD388
Aldose reductase inhibitor
|
IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM). |
PC-61992 |
Fidarestat
Aldose reductase inhibitor
|
Fidarestat (SNK860) is a potent, selective aldose reductase inhibitor with IC50 of 26 nM. |
PC-45580 |
Caficrestat
Aldose reductase inhibitor
|
AT-001 (Caficrestat) is a highly potent, selective inhibitor of aldose reductase enzymatic activity with IC50 of 28.9 pM. |
PC-45922 |
Epalrestat
Aldose reductase inhibitor
|
Epalrestat (ONO-2235) is a noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively. |
PC-22474 |
WJ-39
Aldose reductase inhibitor
|
WJ-39 (Darirestat potassium salt) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. |
PC-22473 |
Darirestat
Aldose reductase inhibitor
|
WJ-38 (Darirestat) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. |
PC-22254 |
AKR1C3 inhibitor 1
AKR1C3 inhibitor
|
AKR1C3 inhibitor 1 is a potent, selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 110 nM, 127-fold selective over AKR1C2. |
PC-20625 |
Imirestat
Aldose reductase inhibitor
|
Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively. |
PC-38679 |
Govorestat
Aldose Reductase inhibitor
|
Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo. |
PC-62883 |
MK-204
|
MK-204 is a potent, selective AKR1B10 inhibitor with IC50 of 80 nM, shows high selective (270-fold) over AKR1B1. |