| Cat. No. |
Product Name |
Information |
| PC-22830 |
APG-1387
IAP antagonist
|
Dasminapant (APG-1387) is a bivalent Smac mimetic and antagonist of inhibitor of apoptosis (IAP) proteins, demonstrates potent antitumor activity inducing apoptosis. |
| PC-22252 |
ARTS mimetic B3
ARTS mimetic, XIAP-p53 inhibitor
|
ARTS mimetic B3 is a small-molecule ARTS-mimeticdirectly binds to the ARTS binding pocket in XIAP-BIR3 with KD of 36 uM, stimulates apoptosis in a wide range of cancer cells but not normal PBMC. |
| PC-21421 |
LLP-3
Survivin-Ran inhibitor
|
LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth. |
| PC-21402 |
Birinapant
IAP inhibitor
|
Birinapant (TL32711) is a bivalent, selective small molecule SMAC mimetic, binds with high affinity to multiple members of the IAP family with Kd of 45 nM and <1 nM for XIAP and cIAP1 respectively. |
| PC-20999 |
LBW242
IAP inhibitor
|
LBW242 (LBW-242) is a small molecule Smac-mimetic / inhibitor of apoptosis protein (IAP) antagonist, binds to XIAP (BIR3) with IC50 of 280 nM. |
