IAP(inhibitors, antagonists, Smac mimic)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-22830	APG-1387 IAP antagonist	Dasminapant (APG-1387) is a bivalent Smac mimetic and antagonist of inhibitor of apoptosis (IAP) proteins, demonstrates potent antitumor activity inducing apoptosis.
PC-22252	ARTS mimetic B3 ARTS mimetic, XIAP-p53 inhibitor	ARTS mimetic B3 is a small-molecule ARTS-mimeticdirectly binds to the ARTS binding pocket in XIAP-BIR3 with KD of 36 uM, stimulates apoptosis in a wide range of cancer cells but not normal PBMC.
PC-21421	LLP-3 Survivin-Ran inhibitor	LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.
PC-21402	Birinapant IAP inhibitor	Birinapant (TL32711) is a bivalent, selective small molecule SMAC mimetic, binds with high affinity to multiple members of the IAP family with Kd of 45 nM and <1 nM for XIAP and cIAP1 respectively.
PC-20999	LBW242 IAP inhibitor	LBW242 (LBW-242) is a small molecule Smac-mimetic / inhibitor of apoptosis protein (IAP) antagonist, binds to XIAP (BIR3) with IC50 of 280 nM.

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