APG-1387 | IAP antagonist | Probechem Biochemicals

Chemical Structure : APG-1387

APG-1387 (Dasminapant, APG1387)

Catalog No.: PC-22830Not For Human Use, Lab Use Only.

Dasminapant (APG-1387) is a bivalent Smac mimetic and antagonist of inhibitor of apoptosis (IAP) proteins, demonstrates potent antitumor activity inducing apoptosis.

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Biological Activity

Dasminapant (APG-1387) is a bivalent Smac mimetic and antagonist of inhibitor of apoptosis (IAP) proteins, demonstrates potent antitumor activity inducing apoptosis.

Physicochemical Properties

M.Wt	1157.42
Formula	C60H72N10O10S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(5S,5′S,8S,8′S,10aR,10′aR)-3,3′-[1,3-Phenylenebis(sulfonyl)]bis[N-(diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-6-oxopyrrolo[1,2-a][1,5]diazocine-8-carboxamide]

References

1. Li N, et al. Cancer Lett. 2016 Oct 10;381(1):14-22.

2. Li BX, et al. J Exp Clin Cancer Res. 2018 Mar 12;37(1):53.

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APG-1387 (Dasminapant, APG1387)

Biological Activity

Physicochemical Properties

References

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