Chemical Structure : LLP-3
CAS No.:
1453835-43-2
LLP-3
(Survivin-Ran inhibitor LLP-3)
Catalog No.: PC-21421Not For Human Use, Lab Use Only.
LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.
LLP-3 does not affect the interaction of Survivin with other chromosomal passenger complex (CPC) proteins.
LLP-3 induces GBM cell apoptosis by inhibiting Survivin complex formation with Ran in a caspase- and p53 status–dependent manner.
LLP-3 inhibits Survivin interaction with Smac/DIABLO and small GTPase Ran.
LLP-3 induces apoptotic cell death in organotypic slice cultures of GBM surgical specimens.
LLP-3 abolishes the growth of patient-derived GBM spheres in vitro and in vivo.
Physicochemical Properties
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M.Wt
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535.00
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Formula
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C32H23ClN2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(3,5-bis(benzyloxy)phenyl)-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
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References
1. Guvenc H, et al. Clin Cancer Res. 2013 Feb 1;19(3):631-42.
2. Galiger C, et al. BMC Cancer. 2023 Nov 25;23(1):1148.
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