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Chemical Structure : IAP antagonist Compound A
Catalog No.: PC-23123Not For Human Use, Lab Use Only.
IAP antagonist Compound A is a highly potent, Smac-mimetic IAP antagonist with equivalent binding affinity to XIAP and cIAP1 in the picomolar range, induces rapid degradation of cIAP1, activates NF-κB signaling via inhibtion of cIAP1 and induces TNFα-dependent apoptosis.
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IAP antagonist Compound A is a highly potent, Smac-mimetic IAP antagonist with equivalent binding affinity to XIAP and cIAP1 in the picomolar range, induces rapid degradation of cIAP1, activates NF-κB signaling via inhibtion of cIAP1 and induces TNFα-dependent apoptosis.
IAP antagonist Compound A competes with Smac for binding to IAPs and also for caspase 9 binding and interacts specifically with the BIR2 and BIR3 domains of cIAP1, cIAP2, and XIAP.
IAP antagonist Compound A (5 nM and 500 nM) exhibits significant killing of Kym1, OVCAR4, and SKOV3 lines.
IAP antagonist Compound A induces rapid degradation of cIAP1 in a binding- and proteasomal-dependent manner.
IAP antagonist Compound A activates NF-κB signaling and induces production of TNFα in an NF-κB-dependent manner in drug-sensitive cell lines.
Brefeldin A and Geldanamycin could blocked cell death induced by compound A.
IAP antagonist Compound A sensitized cells to TNFα-induced cell death.
| M.Wt | 995.27 | |
| Formula | C56H76F2N8O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vince JE, et al. Cell. 2007 Nov 16;131(4):682-93.
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