Chemical Structure : ARTS mimetic B3
CAS No.:
1220108-13-3
ARTS mimetic B3
Catalog No.: PC-22252Not For Human Use, Lab Use Only.
ARTS mimetic B3 is a small-molecule ARTS-mimeticdirectly binds to the ARTS binding pocket in XIAP-BIR3 with KD of 36 uM, stimulates apoptosis in a wide range of cancer cells but not normal PBMC.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ARTS mimetic B3 is a small-molecule ARTS-mimeticdirectly binds to the ARTS binding pocket in XIAP-BIR3 with KD of 36 uM, stimulates apoptosis in a wide range of cancer cells but not normal PBMC.
ARTS mimetic B3 can reduce XIAP levels to promote apoptosis, elevates p53 levels.
ARTS mimetic B3 can disrupt the binding between XIAP and p53, promotes the degradation of XIAP and increases the stability of p53 to promote apoptosis.
ARTS mimetic B3 is able to recapitulate key biochemical and functional properties of ARTS.
The XIAP-antagonist ARTS regulates the levels of p53 by promoting the degradation of XIAP. XIAP directly binds and ubiquitylates p53.
Physicochemical Properties
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M.Wt
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406.44
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Formula
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C22H22N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N1-(1-hydroxy-3-phenylpropan-2-yl)-N2-(4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)oxalamide
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References
1. Abbas R, et al. Apoptosis. 2024 Apr 29. doi: 10.1007/s10495-024-01957-2.
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