HDAC6 inhibitor 4d | HDAC6 inhibitor | Probechem Biochemicals

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Chemical Structure : HDAC6 inhibitor 4d

HDAC6 inhibitor 4d (Nexturastat B)

Catalog No.: PC-27054Not For Human Use, Lab Use Only.

HDAC6 inhibitor 4d (Nexturastat B) is a potent, isoform-selective HDAC6 inhibitor with IC50 of 1.6 nM, shows >500-fold selectivity over HDAC1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HDAC6 inhibitor 4d (Nexturastat B) is a potent, isoform-selective HDAC6 inhibitor with IC50 of 1.6 nM, shows >500-fold selectivity over HDAC1.
HDAC6 inhibitor 4d exhibits antiproliferative effects on several types of melanoma and lymphoma cells.
HDAC6 inhibitor 4d selectively increases acetylated tubulin levels in vitro and elicits an immune response through down-regulating cytokine IL-10.
HDAC6 inhibitor 4d possesses improved capability to inhibit melanoma tumor growth in vivo.

Physicochemical Properties

M.Wt	381.44
Formula	C20H23N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[1-Butyl-3-(1H-indazol-6-yl)ureido]methyl]-N-hydroxybenzamide

References

1. Tavares MT, et al. ACS Med Chem Lett. 2017 Sep 5;8(10):1031-1036.

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HDAC6 inhibitor 4d (Nexturastat B)

Biological Activity

Physicochemical Properties

References

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