| Cat. No. |
Product Name |
Information |
| PC-23991 |
IHCH9033
class I HDAC inhibitor
|
IHCH9033 is a selective, triazole-containing class I HDAC inhibitor, exhibits an increased antitumor effect in FLT3-ITD AML through effectively eliminating leukemia burden and overcoming resistance to FLT3i. |
| PC-23970 |
RG2833
HDAC1/3 inhibitor
|
RG2833 is a potent, orally bioavailable, brain-penetrant histone deacetylase HDAC1/3 inhibitor with IC50 of 60/50 mM respectively. |
| PC-23965 |
HDAC3 inhibitor LSQ-28
HDAC3 inhibitor
|
LSQ-28 is a potent, selective HDAC3 inhibitor with IC50 of 42 nM, >150-fold selective over HDAC1, HDAC2, and HDAC6. |
| PC-23806 |
NSC3852
HDAC inhibitor
|
NSC3852 is a small molecule inhibitor of histone deacetylase (HDAC) with cell differentiation and antiproliferative activity in human breast cancer cells, synergistically enhances the cytotoxicity of olaparib in oral squamous cell carcinoma. |
| PC-23423 |
HDAC6 inhibitor OXHA
HDAC6 inhibitor
|
OXHA is a potent selective HDAC6 inhibitor with IC50 of 3.7 nM, promotes the acetylation of α-tubulin, >40-fold selectivity over HDAC1/2/3/8. |
| PC-23420 |
4-phenylbutyric acid
ER stress inhibitor
|
4-phenylbutyric acid (4-PBA) is a specific endoplasmic reticulum (ER) stress inhibitor, inhibits HDAC activity and increases histone acetylation levels. |
| PC-23348 |
PB131
HDAC6 inhibitor
|
PB131 is a potent, selective and brain-permeable HDAC6 inhibitor with IC50 of 1.8 nM, <100-fold selective over other HDAC isoforms. |
| PC-22845 |
HQ-30
HDAC3 inhibitor, PD-L1 degrader
|
HQ-30 is a potent, dual-acting HDAC3 inhibitor (IC50=89 nM) and PD-L1 degrader (DC50=5.7 uM, Dmax=80% at 10 uM). |
| PC-22801 |
HDAC6 inhibitor 5a
HDAC6 inhibitor
|
HDAC6 inhibitor 5a (MPI-5a) is potent and selective HDAC6 inhibitor with IC50 of 36 nM, >50-fold selectivity over other HDACs |
| PC-22782 |
Leuxinostat
HDAC6 inhibitor
|
Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells. |
| PC-22672 |
SP-1-303
HDAC inhibitor, ATM activator
|
SP-1-303 is a dual-targeting class I HDAC inhibitor and ATM activator with IC50 of 12/14 nM for HDAC1/3, preferentially inhibits ER+ breast cancer growth. |
| PC-22549 |
NT376
class IIa HDAC inhibitor
|
NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes. |
