| Cat. No. |
Product Name |
Information |
| PC-42670 |
Valproic acid
HDAC inhibitor
|
Valproic acid is a HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2. |
| PC-42421 |
EDO-S101
HDAC inhibitor, DNA alkylator
|
EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat. |
| PC-42767 |
Abexinostat
HDAC inhibitor
|
PCI-24781 (Abexinostat, CRA 024781) is a broad spectrum HDAC inhibitor, inhibits pure recombinant HDAC1 with Ki of 7 nM. |
| PC-42126 |
HDACi-4b
HDAC inhibitor
|
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells. |
| PC-25178 |
J22352
HDAC6 inhibitor
|
J22352 is a potent, highly selective HDAC6 inhibitor with IC50 of 4.7 nM, >2000-fold selective for HDAC6 than for class I HDACs (HDAC1, HDAC2 and HDAC3), and with little activity against HDAC8. |
| PC-25167 |
class I HDACs inhibitor JT86
HDAC1 inhibitor
|
class I HDACs inhibitor JT86 is a potent class I HDACs inhibitor with IC50 of 0.72/8.0/2.0 nM for HDAC1/2/3 respectively, 61-fold selectivity over HDAC8 (IC50 44 nM) and 11-fold over HDAC2. |
| PC-25166 |
DAC-001
HDAC1 activator
|
DAC-001 is a small molecule, cell-active activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, displayes significant protection against DNA breaks. |
| PC-25165 |
DAC-003
HDAC1 activator
|
DAC-003 is a small molecule activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, DAC-003 is protective against oxidative stress. |
| PC-25164 |
Compound 5104434
HDAC1 activator
|
Compound 5104434 is a potent, selective activator of HDAC1, selectively activates HDAC1 without significant effects on HDAC2, HDAC3, or HDAC8. |
| PC-25163 |
Exifone
HDAC1 activator
|
Exifone is a potent activator of the deacetylase activity of HDAC1, increases the rate of deacetylation by the enzyme with EC50 of 0.241 uM and EC1.5 value of 0.031 uM. |
| PC-25162 |
Chlopynostat
HDAC1 inhibitor
|
Chlopynostat is a potent, selective HDAC1 inhibitor with IC50 of 67 nM, with no activity against HDAC6/8/10 (IC50>1000 nM). |
| PC-25161 |
CBUD-1001
HDAC1 inhibitor
|
CBUD-1001 is specific small molecule HDAC1 inhibitor with IC50 of 28.1 nM, inhibits HDAC2 and HDAC3 with IC50 values of 158 nM and 404 nM, respectively. |
