| Cat. No. |
Product Name |
Information |
| PC-42126 |
HDACi-4b
HDAC inhibitor
|
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells. |
| PC-24776 |
ITF3107
HDAC6 inhibitor
|
ITF3107 is a potent, selective HDAC6 inhibitor with IC50 of 5 nM, >70-fold more selective for HDAC6over HDAC1/2/3. |
| PC-24775 |
ACY-1083
HDAC6 inhibitor
|
ACY-1083 is a potent, selective and brain-penetrating HDAC6 inhibitor with IC50 of 3 nM, >250-fold more selective for HDAC6 than all other classes of HDAC isoforms. |
| PC-24774 |
ITF3985
HDAC6 inhibitor
|
ITF39856 (ITF-3985) is a potent, selective HDAC6 inhibitor with IC50 of 5 nM, >500-fold selective over HDAC1/2/3. |
| PC-24773 |
ITF3756
HDAC6 inhibitor
|
ITF3756 (ITF-3756) is a potent, selective HDAC6 inhibitor with IC50 of 17 nM, >80-fold selective versus HDAC8 and HDAC Class IIa isoforms (HDAC4, 5, 7, and 9). |
| PC-24769 |
Bavarostat
HDAC6 inhibitor
|
Bavarostat (EKZ-001) is a potent, selective HDAC6 inhibitor with IC50 of 60 nM, 16000-fold selectivity over HDAC1, HDAC2, and HDAC3. |
| PC-24736 |
WMJ-J-09
HDAC inhibitor
|
WMJ-J-09 a potent, hydroxamate based HDAC inhibitor, exhibits potent inhibitory activity against class I HDACs, including HDAC1 (IC50=7.5 nM), HDAC2 (IC50=21.3 nM), HDAC3 (IC50=18.4 nM), and HDAC8 (IC50=90.9 nM), also strongly inhibitsHDAC6 (class IIb) with IC50 of 3.9 nM. |
| PC-24698 |
PAT-1102
HDAC inhibitor
|
PAT-1102 (FNDR-20123) is a novel, potent, orally available HDAC inhibitor with IC50 of 3 nM in cell-free HDAC enzymatic assays, also inhibits Plasmodium HDAC with IC50 of 31 nM. |
| PC-24619 |
Bisthianostat
HDAC inhibitor
|
Bisthianostat (CF367) is an orally bioavailable pan-inhibitor of human histone deacetylase (HDAC) with IC50 of 0.07, 0.26 and 0.79 uM for HDAC1, HDAC2 and HDAC6 respectively. |
| PC-24425 |
DDI199
HDAC/ChE/MAO inhibitor
|
DDI199 (Contilistat) is a novel multi-target molecule by linking Contilisant and Vorinostat (SAHA), inhibits histone deacetylases (HDACs), monoamine oxidases (MAOs) and cholinesterases (ChEs), and modulate histamine H3 (H3R) and Sigma 1 Receptor (S1R) receptors, shows anti-tumor activity against glioma stem cells (GSCs). |
| PC-24323 |
Trichostatin A
HDAC inhibitor
|
Trichostatin A (TSA) is a potent and specific, irreversible inhibitor of class I/II HDACs with IC50 of 1.8 nM for HDAC. |
| PC-24229 |
HDAC6 inhibitor FDR2
HDAC6 inhibitor
|
HDAC6 inhibitor FDR2 is a selective small molecule HDAC6 inhibitor with IC50 of 50.8 nM, shows >100-fold selectivity over HDAC1. |
