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Chemical Structure : EDO-S101
CAS No.: 1236199-60-2
Catalog No.: PC-42421Not For Human Use, Lab Use Only.
EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat.
EDO-S101 (Tinostamustine) displays potent activity in vitro in MM cell lines (IC50=1.6-4.8 uM) and ex vivo in cells isolated from MM patients.
EDO-S101 (Tinostamustine) shows activity in CB17-SCID murine plasmacytoma model and in de novo Vk*MYC mice, also is the only drug with single-agent activity in the multidrug resistant Vk12653 murine model.
| M.Wt | 415.36 | |
| Formula | C19H28Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl- |
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1. Mehrling T, et al. Anticancer Agents Med Chem. 2016;16(1):20-8.
2. López-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20;10(1):127.
3. Besse L, et al. Blood Cancer J. 2017 Jul 28;7(7):e589.
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