| Cat. No. |
Product Name |
Information |
| PC-24425 |
DDI199
HDAC/ChE/MAO inhibitor
|
DDI199 (Contilistat) is a novel multi-target molecule by linking Contilisant and Vorinostat (SAHA), inhibits histone deacetylases (HDACs), monoamine oxidases (MAOs) and cholinesterases (ChEs), and modulate histamine H3 (H3R) and Sigma 1 Receptor (S1R) receptors, shows anti-tumor activity against glioma stem cells (GSCs). |
| PC-24229 |
HDAC6 inhibitor FDR2
HDAC6 inhibitor
|
HDAC6 inhibitor FDR2 is a selective small molecule HDAC6 inhibitor with IC50 of 50.8 nM, shows >100-fold selectivity over HDAC1. |
| PC-24228 |
HDAC6 inhibitor DR-3
HDAC6 inhibitor
|
HDAC6 inhibitor DR-3 is a selective small molecule HDAC6 inhibitor with IC50 of 78.1 nM, shows 100-fold selectivity over HDAC1. |
| PC-24027 |
SR-4370
HDAC inhibitor
|
SR-4370 is a novel HDAC inhibitor with IC50 of 0.13/0.5/0.006/3.4/2.3 μM for HDAC1/2/3/6/8, respectively, also is a latency-reversing agent (LRA) for reactivation of latent HIV-1. |
| PC-23806 |
NSC3852
HDAC inhibitor
|
NSC3852 is a small molecule inhibitor of histone deacetylase (HDAC) with cell differentiation and antiproliferative activity in human breast cancer cells, synergistically enhances the cytotoxicity of olaparib in oral squamous cell carcinoma. |
| PC-23423 |
HDAC6 inhibitor OXHA
HDAC6 inhibitor
|
OXHA is a potent selective HDAC6 inhibitor with IC50 of 3.7 nM, promotes the acetylation of α-tubulin, >40-fold selectivity over HDAC1/2/3/8. |
| PC-23348 |
PB131
HDAC6 inhibitor
|
PB131 is a potent, selective and brain-permeable HDAC6 inhibitor with IC50 of 1.8 nM, <100-fold selective over other HDAC isoforms. |
| PC-22845 |
HQ-30
HDAC3 inhibitor, PD-L1 degrader
|
HQ-30 is a potent, dual-acting HDAC3 inhibitor (IC50=89 nM) and PD-L1 degrader (DC50=5.7 uM, Dmax=80% at 10 uM). |
| PC-22782 |
Leuxinostat
HDAC6 inhibitor
|
Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells. |
| PC-22672 |
SP-1-303
HDAC inhibitor, ATM activator
|
SP-1-303 is a dual-targeting class I HDAC inhibitor and ATM activator with IC50 of 12/14 nM for HDAC1/3, preferentially inhibits ER+ breast cancer growth. |
| PC-22549 |
NT376
class IIa HDAC inhibitor
|
NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes. |
| PC-22482 |
Bufexamac
HDAC6/10 inhibitor
|
Bufexamac (Bufexamic acid) is a selective class IIb (HDAC6, HDAC10) HDAC inhibitor with Kd of 0.53 µM and 0.22 µM respectively, also is a nonsteroida anti-inflammatory agent targeting LTA4H. |
