Chemical Structure : HDAC6 inhibitor OXHA
CAS No.:
2889357-31-5
HDAC6 inhibitor OXHA
Catalog No.: PC-23423Not For Human Use, Lab Use Only.
OXHA is a potent selective HDAC6 inhibitor with IC50 of 3.7 nM, promotes the acetylation of α-tubulin, >40-fold selectivity over HDAC1/2/3/8.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
OXHA is a potent selective HDAC6 inhibitor with IC50 of 3.7 nM, promotes the acetylation of α-tubulin, >40-fold selectivity over HDAC1/2/3/8.
OXHA demonstrate stronger inhibitory activity on HDAC6 than SAHA, significantly promoting α-tubulin acetylation while exerting a comparatively weaker influence on H3 acetylation.
OXHA has potent anti-proliferative activity, comparable to or slightly exceeding that of SAHA.
OXHA effectively inhibits the migratory ability of tumor cells post-irradiation.
OXHA combined IR treatment enhances micronucleus formation in tumor cells, inhibits clone formation ability of tumor cells.
Physicochemical Properties
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M.Wt
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450.50
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Formula
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C24H26N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenyl)-5-phenyloxazole-2-carboxamide
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References
1. Hu H, et al. Mol Biol Rep. 2024 Nov 13;51(1):1151.
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