Chemical Structure : HDAC6 inhibitor DR-3
CAS No.:
2202244-44-6
HDAC6 inhibitor DR-3
Catalog No.: PC-24228Not For Human Use, Lab Use Only.
HDAC6 inhibitor DR-3 is a selective small molecule HDAC6 inhibitor with IC50 of 78.1 nM, shows 100-fold selectivity over HDAC1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HDAC6 inhibitor DR-3 is a selective small molecule HDAC6 inhibitor with IC50 of 78.1 nM, shows 100-fold selectivity over HDAC1.
DR-3 is effective for relieving HDAC6-mediated deacetylation of α-tubulin and exerts anti-fibrogenic effects at the transcript level in the human LX-2 hepatic myofibroblast line.
DR-3 (100 nM) suppresses hepatic stellate cell (HSC) expression of TGF-β1 mRNA in primary rat HSC, suppresses TGFβ1 induced profibrogenic SMAD signaling.
DR-3 shows antifibrogenic activities in human precision-cut liver slice cultures, prevents fibrosis progression in the diseased human liver.
Physicochemical Properties
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M.Wt
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236.27
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Formula
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C12H16N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-hydroxy-4-(morpholinomethyl)benzamide
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References
1. Borrello MT, et al. FEBS J. 2025 Mar 14. doi: 10.1111/febs.70062.
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