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Chemical Structure : NT376
Catalog No.: PC-22549Not For Human Use, Lab Use Only.
NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes.
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NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes.
NT376 shows binding potency with cellular IC50 of 46 nM.
NT376 shows high potency against class-IIa HDAC4 and 5 isoforms and low potency to isoforms from other HDAC classes (HDAC1, class-I; HDAC6, class-IIb; and HDAC11, class-IV).
| M.Wt | 436.41 | |
| Formula | C21H20F4N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu S, et al. Sci Rep. 2024 Jul 2;14(1):15100.
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