Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Leuxinostat
Catalog No.: PC-22782Not For Human Use, Lab Use Only.
Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells.
Leuxinostat shows good selectivity profile over HDAC1 (IC50 = 1203 nM), HDAC3 (IC50 = 2858 nM), HDAC5 (IC50 > 10000 nM), HDAC8 (IC50 = 2446 nM), HDAC10 (IC50 = 4811 nM), and HDAC11 (IC50 = 5570 nM).
Leuxinostat significantly rescued the expansion of HSPCs of FLT3-ITD overexpressing embryos on the HSPCs of the FLT3-ITD zebrafish model of AML.
Leuxinostat enhanced the gilteritinib-induced reduction in cmyb expression.
Leuxinostat showed anticancer activity and therapeutic potential in AML FLT3-ITD cells from AML patients.
| M.Wt | 356.38 | |
| Formula | C18H20N4O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Carullo G, et al. ACS Pharmacol Transl Sci. 2024 Jul 2;7(7):2125-2142.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
