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Chemical Structure : HQ-30
Catalog No.: PC-22845Not For Human Use, Lab Use Only.
HQ-30 is a potent, dual-acting HDAC3 inhibitor (IC50=89 nM) and PD-L1 degrader (DC50=5.7 uM, Dmax=80% at 10 uM).
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HQ-30 is a potent, dual-acting HDAC3 inhibitor (IC50=89 nM) and PD-L1 degrader (DC50=5.7 uM, Dmax=80% at 10 uM).
HQ-30 could effectively and dose-dependently downregulate/degrade PD-L1 in B16–F10 cells via the lysosomal pathway with a DC50 of 5.7 μM and a Dmax of 80% at 10 μM.
HQ-30 could enhance the percentages of CD3+ CD4+ helper T and CD3+ CD8+ cytotoxic T cells, thus activating the tumor immune microenvironmen.
HQ-30 shows antiproliferative activities with IC50 values of 0.43, 1.20, 2.94, and 0.24 μM against HCT-116, B16–F10, MCF-7, and HepG2, respectively.
HQ-30 could effectively achieve PD-L1 downregulation and possess benign in vivo safety and drug-like properties.
| M.Wt | 423.54 | |
| Formula | C22H25N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sun Z, et al. J Med Chem. 2024 Jul 20. doi: 10.1021/acs.jmedchem.4c01062.
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