| Cat. No. |
Product Name |
Information |
| PC-26710 |
SP108
HDAC3 inhibitor
|
SP108 is a potent, selective and brain-permeable HDAC3 inhibitor with IC50 of 15.41 nM, shows 18.72-, 34.65-, >100-, >1000-, >1000-, and >1000-fold selectivity over HDAC1, HDAC2, HDAC8, HDAC6, HDAC4, and HDAC5, respectively. |
| PC-26486 |
GV-001
HDAC6 inhibitor
|
GV-001 is a potent, selective and orally bioavailable HDAC6 inhibitor with IC50 of 1.18 nM, shows >200- and 1900-fold selectivity over HDAC1 and HDAC8. |
| PC-26061 |
PTERi
PTER inhibitor
|
PTERi (PTER inhibitor, PTER-IN-1) is a potent, seletive inhibitor of PTER (phosphotriesterase-related) with IC50 of 43 nM (recombinant mouse PTER activity), >100-fold selectivity for PTER over HDACs and sirtuin (SIRT) deacetylases in vitro. |
| PC-25846 |
GCJ-490A
HDAC inhibitor
|
GCJ-490A is a pan-histone deacetylase (HDAC) inhibitor that exerts potent inhibitory activity against HDAC1, HDAC3, and HDAC6 with IC50 of 3.64, 3.02 and 4.96 nM respectively. |
| PC-25804 |
BKS-112
HDAC6 inhibitor
|
BKS-112 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 42.98 nM, 126-fold selective over HDAC1. |
| PC-25614 |
ITF5924
HDAC6 inhibitor
|
ITF5924 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), shows >100-fold selectivity for HDAC6 over all other HDAC subtypes. |
| PC-25411 |
Parthenolide
HDAC1 inhibitor, USP10 inhibitor
|
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs. |
| PC-25393 |
OCP-001
HDAC1 inhibitor
|
OCP-001 is a potent, highly selective HDAC1 inhibitor, dose-dependently inhibits osteoclast differentiation. |
| PC-25178 |
J22352
HDAC6 inhibitor
|
J22352 is a potent, highly selective HDAC6 inhibitor with IC50 of 4.7 nM, >2000-fold selective for HDAC6 than for class I HDACs (HDAC1, HDAC2 and HDAC3), and with little activity against HDAC8. |
| PC-25167 |
class I HDACs inhibitor JT86
HDAC1 inhibitor
|
class I HDACs inhibitor JT86 is a potent class I HDACs inhibitor with IC50 of 0.72/8.0/2.0 nM for HDAC1/2/3 respectively, 61-fold selectivity over HDAC8 (IC50 44 nM) and 11-fold over HDAC2. |
| PC-25164 |
Compound 5104434
HDAC1 activator
|
Compound 5104434 is a potent, selective activator of HDAC1, selectively activates HDAC1 without significant effects on HDAC2, HDAC3, or HDAC8. |
| PC-25163 |
Exifone
HDAC1 activator
|
Exifone (Adlone) is a potent activator of the deacetylase activity of HDAC1, increases the rate of deacetylation by the enzyme with EC50 of 0.241 uM and EC1.5 value of 0.031 uM. |
