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Chemical Structure : HDAC11 inhibitor PB94
Catalog No.: PC-21403Not For Human Use, Lab Use Only.
HDAC11 inhibitor PB94 is a potent, selective and brain-permeable HDAC11 inhibitor with IC50 of 108 nM, >40-fold over other HDAC isoforms.
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HDAC11 inhibitor PB94 is a potent, selective and brain-permeable HDAC11 inhibitor with IC50 of 108 nM, >40-fold over other HDAC isoforms.
PB94 (20 uM) significantly increases the fatty acylation level of SHMT2 in HEK293T cells.
PB94 exhibits good brain permeability, with brain/plasma ratios of 2.3 at 30 min and 2.2 at 4 h postinjection.
PB94 (3-10 mg/kg) attenuates neuropathic pain and the CCI-induced microgliosis in mice.
| M.Wt | 487.60 | |
| Formula | C29H33N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bai P, et al. J Med Chem. 2023 Nov 16. doi: 10.1021/acs.jmedchem.3c01491.
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