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Chemical Structure : HR488B
Catalog No.: PC-21537Not For Human Use, Lab Use Only.
HR488B is a potent, selective HDAC1 inhibitor with IC50 of 1.24 uM, effectively inhibits the proliferation of CRC cells.
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HR488B is a potent, selective HDAC1 inhibitor with IC50 of 1.24 uM, effectively inhibits the proliferation of CRC cells.
HR488B exhibits a substantially stronger inhibitory effect against HCT116 (IC50 = 0.17 μM) and HT29 (IC50 = 0.59 μM) than SAHA (IC50 = 2.13 μM).
HR488B exhibits good selectivity against HDAC1 over HDAC2 (IC50 = 1.24 nM against HDAC1, IC50 = 10.42 nM against HDAC2), and shows low activity against HDAC8 (IC50 > 10 μM) and HDAC6 (IC50 > 10 μM).
HR488B (10 mg/kg/d) significantly suppresses the tumor growth in an HCT116 xenograft model.
| M.Wt | 488.00 | |
| Formula | C24H26ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Namin Duan, et al. Cell Death Dis. 2023 Dec 7;14(12):801.
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