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Chemical Structure : Givinostat hydrochloride monohydrate
CAS No.: 732302-99-7
Catalog No.: PC-20913Not For Human Use, Lab Use Only.
Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $548 | In stock | |
| 250 mg | Get quote |
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Givinostat (ITF-2357) hydrochloride monohydrate is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
Givinostat (ITF-2357) has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells.
Givinostat (ITF-2357) reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.
Givinostat (ITF-2357) reduces cytokines and protects islet β cells in vivo and in vitro.
| M.Wt | 475.97 | |
| Formula | C24H30ClN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride hydrate |
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1. Li S, et al. J Biol Chem. 2015 Jan 23;290(4):2368-78.
2. Leoni F, et al. Mol Med. 2005 Jan-Dec;11(1-12):1-15.
3. Golay J, et al. Leukemia. 2007 Sep;21(9):1892-900.
4. Guerini V, et al. Leukemia. 2008 Apr;22(4):740-7.
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