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Chemical Structure : Citarinostat
CAS No.: 1316215-12-9
Catalog No.: PC-20984Not For Human Use, Lab Use Only.
Carinostat (ACY-241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with IC50 of 2.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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Carinostat (ACY-241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with IC50 of 2.6 nM.
Carinostat (ACY-241) inhibits HDAC1, HDAC2, HDAC3 and HDAC8 with IC50 of 35 nM, 45 nM, 46 nM and 137 nM, respectively.
Carinostat (ACY-241) enhances the activity of paclitaxel in solid tumor models.
Combination ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma.
| M.Wt | 467.95 | |
| Formula | C24H26ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide |
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1. Huang P, et al. Oncotarget. 2017 Jan 10;8(2):2694-2707.
2. Awad MM, et al. Front Oncol. 2021 Sep 6;11:696512.
3. Ray A, et al. Leukemia. 2018 Mar;32(3):843-846.
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