| Cat. No. |
Product Name |
Information |
| PC-25162 |
Chlopynostat
HDAC1 inhibitor
|
Chlopynostat is a potent, selective HDAC1 inhibitor with IC50 of 67 nM, with no activity against HDAC6/8/10 (IC50>1000 nM). |
| PC-25110 |
Martinostat
HDAC inhibitor
|
Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms. |
| PC-24921 |
RM-3-22
HDAC inhibitor
|
RM-3-22 is a TAZQ-based hydroxamic acid derivative and potent HDAC inhibitor with IC50 of 49.9 nM, 68.5 nM, and 12.9 nM for HDAC1, HDAC3, and HDAC6 isoforms respectively. |
| PC-24777 |
MI-192
HDAC2/HDAC3 inhibitor
|
MI-192 is a potent, selective HDAC2 and HDAC3 inhibitor with IC50 of 30 nM and 16 nM, respectively. |
| PC-24773 |
ITF3756
HDAC6 inhibitor
|
ITF3756 (ITF-3756) is a potent, selective HDAC6 inhibitor with IC50 of 17 nM, >80-fold selective versus HDAC8 and HDAC Class IIa isoforms (HDAC4, 5, 7, and 9). |
| PC-24769 |
Bavarostat
HDAC6 inhibitor
|
Bavarostat (EKZ-001) is a potent, selective HDAC6 inhibitor with IC50 of 60 nM, 16000-fold selectivity over HDAC1, HDAC2, and HDAC3. |
| PC-24736 |
WMJ-J-09
HDAC inhibitor
|
WMJ-J-09 is a potent, hydroxamate based HDAC inhibitor, exhibits potent inhibitory activity against class I HDACs, including HDAC1 (IC50=7.5 nM), HDAC2 (IC50=21.3 nM), HDAC3 (IC50=18.4 nM), and HDAC8 (IC50=90.9 nM), also strongly inhibitsHDAC6 (class IIb) with IC50 of 3.9 nM. |
| PC-24619 |
Bisthianostat
HDAC inhibitor
|
Bisthianostat (CF367) is an orally bioavailable pan-inhibitor of human histone deacetylase (HDAC) with IC50 of 0.07, 0.26 and 0.79 uM for HDAC1, HDAC2 and HDAC6 respectively. |
| PC-24323 |
Trichostatin A
HDAC inhibitor
|
Trichostatin A (TSA) is a potent and specific, irreversible inhibitor of class I/II HDACs with IC50 of 1.8 nM for HDAC. |
| PC-24022 |
HDAC11 inhibitor B6
HDAC11 inhibitor
|
HDAC11 inhibitor B6 is a potent, highly selective HDAC11 inhibitor with IC50 of 51.1 nM, >90-fold selective over HDAC8 and shows no activity against all other HDAC subtypes. |
| PC-23992 |
DS-103
HDAC inhibitor
|
DS-103 is a potent HDAC inhibitor with IC50 of 29/123/23/367 nM for HDAC1/2/3/6, weakly inhibits HDAC8 and no activity against class IIa member HDAC4. |
| PC-23991 |
IHCH9033
class I HDAC inhibitor
|
IHCH9033 is a selective, triazole-containing class I HDAC inhibitor, exhibits an increased antitumor effect in FLT3-ITD AML through effectively eliminating leukemia burden and overcoming resistance to FLT3i. |
