| Cat. No. |
Product Name |
Information |
| PC-49250 |
TYA-018
HDAC6 inhibitor
|
TYA-018 (TYA018) is a potent, isoform-selective inhibitor of HDAC6 with IC50 of 10 nM, inhibits tubulin acetylation (Ac-Tubulin) with EC50 of 120 nM in cell-based assay in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). |
| PC-49104 |
MPT0B390
HDAC1/2 inhibitor
|
MPT0B390 (B390) is a selective HDAC1/2 inhibitor and an effective inducer of metalloproteinase 3 (TIMP3), significantly upregulates TIMP3 expression in colorectal cancer cells. |
| PC-49072 |
KH-259
HDAC6 inhibitor
|
KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM). |
| PC-49004 |
Dacinostat
HDAC inhibitor
|
Dacinostat (NVP-LAQ824) is a potent histone deacetylase (HDAC) inhibitor with IC50 of 32 nM, transcriptionally activates the p21 promoter in reporter gene assays with AC50 of 0.3 uM. |
| PC-38799 |
NQN-1
HDAC6 inhibitor
|
NQN-1 is a highly selective, small molecule HDAC6 inhibitor with IC50 of 5.54 uM and Ki of 1.30 uM. |
| PC-38796 |
A452
HDAC6 inhibitor
|
A452 is a potent and selective HDAC6 inhibitor, effectively inhibits the cell growth and viability of various cancer cell types, irrespective of p53 status. |
| PC-73237 |
UBD253
HDAC6 inhibitor
|
UBD253 (SGC-UBD253) is a potent, selective ubiquitin chemical probe for ubiquitin binding domain of HDAC6 with Kd of 84 nM (SPR), inhibits the HDAC6-ISG15 interaction (EC50=1.9 uM, nanoBRET). |
| PC-73193 |
Rocilinostat
HDAC6 inhibitor
|
Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor with IC50 of 5 nM. |
| PC-73192 |
Domatinostat
Class I HDAC inhibitor
|
Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20/1.12/0.57 uM for HDAC1/2/3, repectively. |
| PC-72886 |
IRBM6
Class I HDAC inhibitor
|
IRBM6 (Class I HDAC-IN-6) is a potent, class I selective HDAC inhibitor with EC50 of 50 nM (HeLa cellular), HDAC1/2/3 IC50 of 1.7/2.8/1.1 nM. |
| PC-72875 |
MJM-1
HDAC inhibitor
|
MJM-1 is a small-molecule brain-penetrant HDAC inhibitor that increases the overall level of histone 3 (H3) acetylation in prostate cancer cell line. |
| PC-72785 |
T-518
HDAC6 inhibitor
|
T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM. |
