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Chemical Structure : YSL-109
Catalog No.: PC-49678Not For Human Use, Lab Use Only.
YSL-109 (YSL109) is a potent, highly selective small molecule inhibitor of HDAC6 with IC50 of 0.537 nM, >4000-fold selectivity over HDAC1 and HDAC8.
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YSL-109 (YSL109) is a potent, highly selective small molecule inhibitor of HDAC6 with IC50 of 0.537 nM, >4000-fold selectivity over HDAC1 and HDAC8.
YSL-109 showed potent activity against hepatocellular carcinoma (HepG2 cell line, IC50=3.39 µM), breast cancer (MCF-7 cell line, IC50=3.41 µM; HCC1954 cell line, IC50=3.41 µM) and neuroblastoma (SH-SY5Y cell line, IC50=6.42 µM).
YSL-109 showed an antiproliferative activity TNBC cell line (MDA-MB231) with IC50 of 50 uM, lesser toxic on fibroblast.
| M.Wt | 390.48 | |
| Formula | C24H26N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sixto-López Y, et al. Sci Rep. 2020 Jun 26;10(1):10462.
2. Sixto-López Y, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jan 25. doi: 10.1007/s00210-023-02396-7.
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