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Chemical Structure : DKFZ-748
CAS No.: 2490709-68-5
Catalog No.: PC-49363Not For Human Use, Lab Use Only.
DKFZ-748 (DKFZ748) is a potent, specific HDAC10 inhibitor with cellular IC50 of 22 nM, >500-fold selectivity over other HDAC isozymes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DKFZ-748 (DKFZ748) is a potent, specific HDAC10 inhibitor with cellular IC50 of 22 nM, >500-fold selectivity over other HDAC isozymes.
Inhibition of HDAC10 activity via DKFZ-748 (5 uM) suppressed colon cancer cell growth rescue by N8-AcSpd in HCT116 WT cells.
DKFZ-748 treatment effectively prevented restoration of polyamine homeostasis by N8-AcSpd in HCT116 cells.
DKFZ-748 showed dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model.
DKFZ-748 is a valuable chemical probe for studies on the enigmatic biology of HDAC10 and acetylated polyamines in both physiological and pathological settings.
| M.Wt | 329.400 | |
| Formula | C18H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-((4-(hydroxyamino)-4-oxobutyl)(methyl)amino)ethyl)-1-naphthamide |
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1. Raphael R. Steimbach, et al. J. Am. Chem. Soc. 2022.
2. Tracy Murray Stewart, et al. J Biol Chem. 2022 Aug 19;298(10):102407.
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