You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-HDAC-KH-259
KH-259

Chemical Structure : KH-259

CAS No.: 3023019-93-1

KH-259 (KH259)

Catalog No.: PC-49072Not For Human Use, Lab Use Only.

KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM).

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM).
    KH-259 (10 mg/kg, i.p.) demonstrated antidepressant activity and increased acetylated α-tubulin in the brain without promoting acetylated histone H3K9.

    Physicochemical Properties

    M.Wt 339.439
    Formula C20H25N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-hydroxy-4-((4-(1-phenylethyl)piperazin-1-yl)methyl)benzamide

    References

    1. Kosuke Hashimoto, et al. ACS Med. Chem. Lett. 2022

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: