You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-HDAC-TYA-018
TYA-018

Chemical Structure : TYA-018

CAS No.: 2653254-31-8

TYA-018 (TYA018)

Catalog No.: PC-49250Not For Human Use, Lab Use Only.

TYA-018 (TYA018) is a potent, isoform-selective inhibitor of HDAC6 with IC50 of 10 nM, inhibits tubulin acetylation (Ac-Tubulin) with EC50 of 120 nM in cell-based assay in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs).

Packing Price Stock Quantity
2 mg $198 In stock
5 mg $348 In stock
10 mg $528 In stock
25 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TYA-018 (TYA018) is a potent, isoform-selective inhibitor of HDAC6 with IC50 of 10 nM, inhibits tubulin acetylation (Ac-Tubulin) with EC50 of 120 nM in cell-based assay in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs).
TYA-018 displays >2500-fold selectivity compared with other zinc-dependent HDACs, shows no any off-target activity of on nuclear HDACs by measuring acetylated lysine on histone H3 and H4.
TYA-018 (15 mg/kg by oral gavage) reduced Nppb expression and sarcomere damage and prevented heart failure in BAG3 cardiomyocyte-knockout (BAG3cKO) mouse model of Dilated cardiomyopathy (DCM), partially restored protein expression of FLNC, PINK1, VDAC2, and p62 to amounts similar to WT mice.
TYA-018 treatment reduces mitochondrial content, decreases apoptotic nuclei, and increases LC3 puncta in hearts of BAG3cKO mice.
TYA-018 treatment enriches targets associated with muscle contraction, protein and fatty acid metabolism, and oxidative phosphorylation in BAG3cKO mice.

Physicochemical Properties

M.Wt 434.861
Formula C15H13ClF2N4O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-chlorophenyl)-N-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)thiazol-2-yl)methyl)ethanesulfonamide

References

1. Jin Yang, et al. Sci Transl Med. 2022 Jul 6;14(652):eabl5654.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: