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Chemical Structure : NQN-1
Catalog No.: PC-38799Not For Human Use, Lab Use Only.
NQN-1 is a highly selective, small molecule HDAC6 inhibitor with IC50 of 5.54 uM and Ki of 1.30 uM.
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NQN-1 is a highly selective, small molecule HDAC6 inhibitor with IC50 of 5.54 uM and Ki of 1.30 uM.
NQN-1 displayed cell killing activity consistent with it's HDAC6 inhibitory activity in MTS cell proliferation/toxicity assays, selectively induced hyperacetylated tubulin without an increase in histone H3 and H4 acetylation.
NQN-1 induces Hsp90 acetylation and causes a decrease in Hsp90 client protein FLT-3, STAT5, and phosphorylated-Erk levels in the human acute myeloid leukemia cell line, MV4-11, with associated cell death.
| M.Wt | 263.296 | |
| Formula | C17H13NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Elizabeth S Inks, et al. ACS Chem Biol. 2012 Feb 17;7(2):331-9.
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