| Cat. No. |
Product Name |
Information |
| PC-70244 |
CGK1026
HDAC inhibitor
|
CGK1026 is a small molecule that inhibits human telomerase reverse transcriptase (hTERT) expression, inhibits HDAC activity with IC50 of 100 nM. |
| PC-70352 |
LB-205
HDAC inhibitor
|
LB-205 is a Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo. |
| PC-70299 |
WT-161
HDAC6 inhibitor
|
WT-161 (WT161) is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 0.4 nM. |
| PC-60830 |
HDAC6 inhibitor NCT-14b
HDAC6 inhibitor
|
HDAC6 inhibitor NCT-14b is a potent, selective HDAC6 inhibitor with IC50 of 84 nM, with IC50s of >3.5 uM for the other HDAC isoforms. |
| PC-60828 |
T326
HDAC3 inhibitor
|
T326 is a potent and selective HDAC3 inhibitor with IC50 of 0.26 uM, with no activity against HDAC1/4/6/8. |
| PC-60827 |
T247
HDAC3 inhibitor
|
T247 is a potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8. |
| PC-60692 |
BML-281
HDAC6 inhibitor
|
BML-281 (CAY10603) is a potent, selective HDAC6 inhibitor with IC50 of 0.002 nM, weakly inhibits HDAC3 (IC50=0.42 nM) and >50,000-fold selectivity over HDAC1/2/8/10. |
| PC-70234 |
Splitomicin
Sir2p inhibitor
|
Splitomicin (1-Naphthalenepropanoic Acid) is a selecitve small molecule inhibitor of Sir2p histone deacetylase, displaying higher activity in vivo (minimal inhibitory concentration= 0.49 uM) than in vitro (IC50=60 uM). |
| PC-70233 |
SK-7041
HDAC inhibitor
|
SK-7041 is a potent HDAC inhibitor with IC50 of 172 nM, preferentially inhibit class I HDAC1 and HDAC2 than the other HDAC isotypes. |
| PC-60416 |
trans CM-414
PDE5/HDAC inhibitor
|
trans CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM). |
| PC-60415 |
CM-414
PDE5/HDAC inhibitor
|
CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM). |
| PC-60414 |
CM-414
PDE5/HDAC inhibitor
|
CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM). |
