| Cat. No. |
Product Name |
Information |
| PC-60830 |
HDAC6 inhibitor NCT-14b
HDAC6 inhibitor
|
HDAC6 inhibitor NCT-14b is a potent, selective HDAC6 inhibitor with IC50 of 84 nM, with IC50s of >3.5 uM for the other HDAC isoforms. |
| PC-60828 |
T326
HDAC3 inhibitor
|
T326 is a potent and selective HDAC3 inhibitor with IC50 of 0.26 uM, with no activity against HDAC1/4/6/8. |
| PC-60827 |
T247
HDAC3 inhibitor
|
T247 is a potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8. |
| PC-60692 |
BML-281
HDAC6 inhibitor
|
BML-281 (CAY10603) is a potent, selective HDAC6 inhibitor with IC50 of 0.002 nM, weakly inhibits HDAC3 (IC50=0.42 nM) and >50,000-fold selectivity over HDAC1/2/8/10. |
| PC-70234 |
Splitomicin
Sir2p inhibitor
|
Splitomicin (1-Naphthalenepropanoic Acid) is a selecitve small molecule inhibitor of Sir2p histone deacetylase, displaying higher activity in vivo (minimal inhibitory concentration= 0.49 uM) than in vitro (IC50=60 uM). |
| PC-70233 |
SK-7041
HDAC inhibitor
|
SK-7041 is a potent HDAC inhibitor with IC50 of 172 nM, preferentially inhibit class I HDAC1 and HDAC2 than the other HDAC isotypes. |
| PC-60416 |
trans CM-414
PDE5/HDAC inhibitor
|
trans CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM). |
| PC-60415 |
CM-414
PDE5/HDAC inhibitor
|
CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM). |
| PC-60414 |
CM-414
PDE5/HDAC inhibitor
|
CM-414 is a first-in-class, dual inhibitor of PDE5 and HDAC that inhibits HDAC1/2/3/6 (IC50=310/490/322/91 nM, respectively) and PDE5 (IC50=60 nM). |
| PC-60407 |
AR-42
HDAC inhibitor
|
AR-42 (HDAC-42, OSU-HDAC42, NSC-D736012) is a potent pan-HDAC inhibitor with IC50 of 16-30 nM, inhibits cell proliferation of P815, C2, and BR cells with IC50 of 0.65, 0.30, and 0.23 uM, respectively. |
| PC-70123 |
Merck60
HDAC1/2 inhibitor
|
Merck60 (BRD 6929, Compound-60) is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively. |
| PC-70106 |
ACY-775
HDAC6 inhibitor
|
ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability. |
