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Chemical Structure : Rocilinostat
CAS No.: 1316214-52-4
Catalog No.: PC-73193Not For Human Use, Lab Use Only.
Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 500 mg | $328 | In stock | |
| 1 g | Get quote |
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Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor with IC50 of 5 nM.
Ricolinostat (ACY-1215) displays 10-12 fold less active against HDAC1, HDAC2, and HDAC3 (class I HDACs), minimal activity (IC50 > 1 uM) against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2, and has slight activity against HDAC8 (IC50=0.1 uM).
ACY-1215 induces dose-dependent cytotoxicity in MM cells (IC50=2-8 uM), induces synergistic anti-MM activity in combination with bortezomib.
ACY-1215 in combination with bortezomib induces significant anti-MM activity in vivo.
| M.Wt | 433.5 | |
| Formula | C24H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide |
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1. Santo L, et al. Blood. 2012 Mar 15;119(11):2579-89.
2. Amengual JE, et al. Clin Cancer Res. 2015 Oct 15;21(20):4663-75.
3. Mishima Y, et al. Br J Haematol. 2015 May;169(3):423-34.
4. Dasmahapatra G, et al. Mol Cancer Ther. 2014 Dec;13(12):2886-97.
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