| Cat. No. |
Product Name |
Information |
| PC-42421 |
EDO-S101
HDAC inhibitor
|
EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat. |
| PC-42767 |
PCI-24781
HDAC inhibitor
|
PCI-24781 (Abexinostat, CRA 024781) is a broad spectrum HDAC inhibitor, inhibits pure recombinant HDAC1 with Ki of 7 nM. |
| PC-42126 |
HDACi-4b
HDAC inhibitor
|
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells. |
| PC-23348 |
PB131
HDAC6 inhibitor
|
PB131 is a potent, selective and brain-permeable HDAC6 inhibitor with IC50 of 1.8 nM, <100-fold selective over other HDAC isoforms. |
| PC-22845 |
HQ-30
HDAC3 inhibitor, PD-L1 degrader
|
HQ-30 is a potent, dual-acting HDAC3 inhibitor (IC50=89 nM) and PD-L1 degrader (DC50=5.7 uM, Dmax=80% at 10 uM). |
| PC-22801 |
HDAC6 inhibitor 5a
HDAC6 inhibitor
|
HDAC6 inhibitor 5a (MPI-5a) is potent and selective HDAC6 inhibitor with IC50 of 36 nM, >50-fold selectivity over other HDACs |
| PC-22791 |
Givinostat
HDAC inhibitor
|
Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. |
| PC-22782 |
Leuxinostat
HDAC6 inhibitor
|
Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells. |
| PC-22672 |
SP-1-303
HDAC inhibitor, ATM activator
|
SP-1-303 is a dual-targeting class I HDAC inhibitor and ATM activator with IC50 of 12/14 nM for HDAC1/3, preferentially inhibits ER+ breast cancer growth. |
| PC-22549 |
NT376
class IIa HDAC inhibitor
|
NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes. |
| PC-22482 |
Bufexamac
HDAC6/10 inhibitor
|
Bufexamac (Bufexamic acid) is a selective class IIb (HDAC6, HDAC10) HDAC inhibitor with Kd of 0.53 µM and 0.22 µM respectively, also is a nonsteroida anti-inflammatory agent targeting LTA4H. |
| PC-22427 |
PCI-34051
HDAC8 inhibitor
|
PCI-34051 is a potent, specific HDAC8 inhibitor with IC50 of 10 nM, >200-fold selectivity over other HDAC isoforms. |
