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Chemical Structure : HPOB
CAS No.: 1429651-50-2
Catalog No.: PC-45702Not For Human Use, Lab Use Only.
HPOB is a potent and selective HDAC6 inhibitor (IC50=56 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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HPOB is a potent and selective HDAC6 inhibitor (IC50=56 nM).
HPOB shows IC50>1.7 uM for the other HDACs, more potent than tubacin.
HPOB selectively inhibits HDAC6 catalytic activity in vivo and in vitro.
HPOB causes growth inhibition of normal and transformed cells but does not induce cell death.
HPOB enhances the effectiveness of DNA-damaging anticancer drugs in transformed cells but not normal cells.
| M.Wt | 314.3358 | |
| Formula | C17H18N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl- |
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1. Lee JH, et al. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9.
2. Li ZY, et al. Neurochem Int. 2016 Oct;99:239-51.
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