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Chemical Structure : ACY-738
CAS No.: 1375465-91-0
Catalog No.: PC-45609Not For Human Use, Lab Use Only.
ACY-738 (ACY738) is a potent and specific HDAC6 inhibitor (IC50=1.7 nM) with improved brain bioavailability.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $578 | In stock | |
| 100 mg | Get quote |
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ACY-738 (ACY738) is a potent and specific HDAC6 inhibitor (IC50=1.7 nM) with improved brain bioavailability.
ACY-738 displays 60-1500 fold selectivity over class I HDACs.
ACY-738 induces dramatic increase in α-tubulin acetylation in brain and stimulates mouse exploratory behaviors.
ACY-738 increases the innervation of the neuromuscular junctions in the gastrocnemius muscle and improves the motor and sensory nerve conduction in the mutant HSPB1-induced CMT2 mouse model.
| M.Wt | 270.2866 | |
| Formula | C14H14N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
5-Pyrimidinecarboxamide, N-hydroxy-2-[(1-phenylcyclopropyl)amino]- |
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1. Jochems J, et al. Neuropsychopharmacology. 2014 Jan;39(2):389-400.
2. Regna NL, et al. Clin Immunol. 2016 Jan;162:58-73.
3. Benoy V, et al. Neurotherapeutics. 2017 Apr;14(2):417-428.
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