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CXD101

Chemical Structure : CXD101

CAS No.: 934828-12-3

CXD101 (Zabadinostat, CXD-101)

Catalog No.: PC-42249Not For Human Use, Lab Use Only.

Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively, has no activity against class II HDACs.

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Biological Activity

Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively, has no activity against class II HDACs.
Zabadinostat (CXD101) shows IC50 of 0.2-15 uM against colon, lung, non-Hodgkin lymphoma, and myeloma cell lines.
Zabadinostat (CXD101) treatment increased expression of MHC class I and II genes in a variety of cells, including dendritic cells (DCs) and healthy tissue.

Physicochemical Properties

M.Wt 403.52
Formula C24H29N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Benzamide, N-(2-aminophenyl)-4-[1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-4-piperidinyl]-

References

1. PCT Int. Appl. (2007), WO 2007045844 A1 20070426.
2. Geng Liu, et al. Commun Biol. 2023 Jan 26;6(1):102.
3. Eyre TA, et al. Cancer. 2019 Jan 1;125(1):99-108.

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