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Chemical Structure : Entinostat
CAS No.: 209783-80-2
Catalog No.: PC-42902Not For Human Use, Lab Use Only.
Entinostat (MS275) is a potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $138 | In stock | |
| 250 mg | $228 | In stock | |
| 1 g | Get quote |
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Entinostat (MS275) is a potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
Entinostat (MS275) shows no inhibition on HDAC8/4/5/7/9/6/10 (IC50>10 uM).
Entinostat (MS275) induces accumulation of p21WAF1/CIP1 and gelsolin in K562 cell.
Entinostat (MS275) reduce S-phase cells and induce G1-phase cells in A2780 cell.
| M.Wt | 376.4085 | |
| Formula | C21H20N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester |
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1. Saito A, et al. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4592-7.
2. Lauffer BE, et al. J Biol Chem. 2013 Sep 13;288(37):26926-43.
3. Rosato RR, et al. Cancer Res. 2003, 63(13), 3637-3645.
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