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BML-210

Chemical Structure : BML-210

CAS No.: 537034-17-6

BML-210 (BML210;BML 210)

Catalog No.: PC-45619Not For Human Use, Lab Use Only.

BML-210 is a small molecule histone deacetylase (HDAC) inhibitor that induces Ac-histone in A549 cells with EC50 of 181 uM.

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Biological Activity

BML-210 is a small molecule histone deacetylase (HDAC) inhibitor that induces Ac-histone in A549 cells with EC50 of 181 uM.
BML-210 inhibits the growth of all cell lines and promotes apoptosis in the human leukemia cell lines (NB4, HL-60, THP-1, and K562).
BML-210 induces growth inhibition and apoptosis and downregulates HDAC1-5 and DAPC complex expression levels in cervical cancer cells.

Physicochemical Properties

M.Wt 339.4314
Formula C20H25N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Octanediamide, N1-(2-aminophenyl)-N8-phenyl-

References

1. Savickiene J, et al. Eur J Pharmacol. 2006 Nov 7;549(1-3):9-18.

2. Wong JC, et al. J Am Chem Soc. 2003 May 14;125(19):5586-7.

3. Borutinskaite VV, et al. Mol Biol Rep. 2012 Dec;39(12):10179-86.

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