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Chemical Structure : UF-010
CAS No.: 537672-41-6
Catalog No.: PC-45583Not For Human Use, Lab Use Only.
UF-010 is a potent and selective inhibitor of class I HDACs with IC50s of 0.5/0.1/0.06/1.5/9.1/15.3/44.5 uM for HDAC1/2/3/8/6/10/11 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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UF-010 is a potent and selective inhibitor of class I HDACs with IC50s of 0.5/0.1/0.06/1.5/9.1/15.3/44.5 uM for HDAC1/2/3/8/6/10/11 respectively.
UF-010 shows no effect on HDAC4/5/7/9(>100 uM).
UF-010 induces the accumulation of protein acetylation and inhibits proliferation of NCI-60 panel of cancer cell lines (mean GI50=2.94 uM).
UF-010 is a competitive with a fast-on/slow-off HDAC-binding mechanism.
| M.Wt | 271.1536 | |
| Formula | C11H15BrN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 4-bromo-, 2-butylhydrazide |
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1. Wang Y, et al. Chem Biol. 2015 Feb 19;22(2):273-84.
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