| Cat. No. |
Product Name |
Information |
| PC-21991 |
DNMT/HDACi 15a
DNMT/HDAC inhibitor
|
DNMT/HDACi 15a is a potent, dual DNMT and HDAC inhibitor with IC50 of 57, 17 nM for HDAC1, HDAC6 respectively. |
| PC-21870 |
SP-2-225
HDAC6 inhibitor
|
SP-2-225 is a potent, selective HDAC6 inhibitor, improves antitumor immune responses and prevent tumor relapse after radiotherapy. |
| PC-21844 |
RBC1HI
HDAC1/2 inhibitor
|
RBC1HI is a novel small molecule HDAC1/HDAC2 inhibitor, attenuates behavioral manifestations of oxycodone withdrawal, especially in mice with neuropathic pain. |
| PC-21650 |
Tefinostat
HDAC inhibitor
|
Tefinostat (CHR-2845) is a monocyte/macrophage targeted pan histone deacetylase (HDAC) inhibitor, which is cleaved into the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). |
| PC-21608 |
CM-444
HDAC inhibitor
|
CM-444 is a potent histone deacetylase (HDAC) inhibitor with IC50 of 7/51/18/531 nM for HDAC1/2/3/6 respectively, also inhibits DNMT1 with IC50 of 2160 nM. |
| PC-21607 |
CM-1758
HDAC inhibitor
|
CM-1758 is a novel histone deacetylase (HDAC) inhibitor with IC50 of 5 nM and 126 nM for HDAC1 and HDAC6, respectively. |
| PC-21537 |
HR488B
HDAC1 inhibitor
|
HR488B is a potent, selective HDAC1 inhibitor with IC50 of 1.24 uM, effectively inhibits the proliferation of CRC cells. |
| PC-21520 |
YSR734
HDAC inhibitor
|
YSR734 is a first-in-class covalent HDACs inhibitor with IC50 of 0.109 uM, 0.154 uM and 0.143 uM for HDAC1, HDAC2, and HDAC3, sparing other deacetylases (HDAC4-HDAC10, IC50>10 uM). |
| PC-21403 |
HDAC11 inhibitor PB94
HDAC11 inhibitor
|
HDAC11 inhibitor PB94 is a potent, selective and brain-permeable HDAC11 inhibitor with IC50 of 108 nM, >40-fold over other HDAC isoforms. |
| PC-21394 |
PB118
HDAC6 inhibitor.
|
PB118 is a potent, selective HDAC6 inhibitor with IC50 of 5.6 nM, shows >1000 times selectively towards HDAC1, reduces alzheimer's disease neuropathology. |
| PC-21309 |
KPZ560
HDAC1/2 inhibitor
|
KPZ560 is a potent, HDAC1/2-selective inhibitor with IC50 of 12/68 nM, respectively. |
| PC-21304 |
Mz325
Sirt2/HDAC6 inhibitor
|
Mz325 is a potent, selective, dual inhibitor of Sirt2/HDAC6 with IC50 of 320/43 nM, respectively. |
