| Cat. No. |
Product Name |
Information |
| PC-26486 |
GV-001
HDAC6 inhibitor
|
GV-001 is a potent, selective and orally bioavailable HDAC6 inhibitor with IC50 of 1.18 nM, shows >200- and 1900-fold selectivity over HDAC1 and HDAC8. |
| PC-26373 |
CDC1011
UCP1 activator, HDAC inhibitor
|
CDC1011 is a small molecule uncoupling protein 1 (UCP1) activator, significantly upregulates the transcriptional expression of UCP1 in differentiated SW872 adipocytes, functions as an HDAC inhibitor. |
| PC-26251 |
AMC-3-030
HDAC/proteasome inhibitor
|
AMC-3-030 is a potent, dual HDAC6/proteasome inhibitor with IC50 of 884 nM for HDAC6 and IC50 of 4.17 nM in cell-free 20S proteasomal chymotrypsin-like activity assay. |
| PC-26231 |
Scriptaid
HDAC inhibitor
|
Scriptaid (Scriptide, GCK1026) is a potent small molecule histone deacetylase (HDAC) inhibitor. |
| PC-26230 |
Pyroxamide
HDAC inhibitor
|
Pyroxamide is a potent inhibitor of HDAC with IC50 of 100 nM for HDAC1, causes the accumulation of acetylated core histones in murine erythroleukemia (MEL) cells. |
| PC-26229 |
VS-186B
HDAC inhibitor
|
VS-186B is a small molecule HDAC inhibitor with IC50 of 2.5 uM, inhibits Class I and II HDACs in a dose-dependent manner. |
| PC-26064 |
UVI5008
Epigenetic inhibitor
|
UVI5008 is a small molecule epigenetic modifier/modulator that inhibits histone deacetylases, sirtuins, and DNA methyltransferases, affects the death receptor (DR) pathway and reactive oxygen species (ROS) production in cancer cells. |
| PC-25935 |
Colrestat
class I HDAC inhibitor
|
Colrestat is a potent, selective inhibitor of class I histone deacetylases (HDACs) with IC50 of 41.2 nM, 52.5 nM and 74.3 nM for HDAC1, HDAC2 and HDAC3 respectively. |
| PC-25904 |
Mesinostat
HDAC6 inhibitor
|
Mesinostat is a potent and selective HDAC6 inhibitor with IC50 of 7.7 nM, >200-fold selective over HDAC1. |
| PC-25868 |
EKZ-438
HDAC6 inhibitor
|
EKZ-438 is a potent, selective, CNS-penetrant and orally bioavailable HDAC6 inhibitor with IC50 of 12 nM, >8,500-fold selectivity for HDAC6 versus all other HDAC6 paralogs. |
| PC-25804 |
BKS-112
HDAC6 inhibitor
|
BKS-112 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 42.98 nM, 126-fold selective over HDAC1. |
| PC-25614 |
ITF-6475
HDAC6 inhibitor
|
ITF-6475 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), ITF-6475 is highly selective for the CD2 domain (zHDAC6-CD2), shows <10,000-fold selectivity for HDAC6 over all other HDAC subtypes. |
