| Cat. No. |
Product Name |
Information |
| PC-22801 |
HDAC6 inhibitor 5a
HDAC6 inhibitor
|
HDAC6 inhibitor 5a (MPI-5a) is potent and selective HDAC6 inhibitor with IC50 of 36 nM, >50-fold selectivity over other HDACs |
| PC-22782 |
Leuxinostat
HDAC6 inhibitor
|
Leuxinostat is a potent, specific HDAC6 inhibitor with IC50 of 30 nM, induces apoptosis in FLT3-ITD AML cells. |
| PC-22672 |
SP-1-303
HDAC inhibitor, ATM activator
|
SP-1-303 is a dual-targeting class I HDAC inhibitor and ATM activator with IC50 of 12/14 nM for HDAC1/3, preferentially inhibits ER+ breast cancer growth. |
| PC-22549 |
NT376
class IIa HDAC inhibitor
|
NT376 is a highly potent, selective class-IIa HDACs inhibitor with cellular IC50 of 32 nM in HT-29 cell line, >100-fold selectivity over other HDAC classes. |
| PC-22482 |
Bufexamac
HDAC6/10 inhibitor
|
Bufexamac (Bufexamic acid) is a selective class IIb (HDAC6, HDAC10) HDAC inhibitor with Kd of 0.53 µM and 0.22 µM respectively, also is a nonsteroida anti-inflammatory agent targeting LTA4H. |
| PC-22427 |
PCI-34051
HDAC8 inhibitor
|
PCI-34051 is a potent, specific HDAC8 inhibitor with IC50 of 10 nM, >200-fold selectivity over other HDAC isoforms. |
| PC-22259 |
QAPHA
Tubulin/HDAC6 inhibitor
|
QAPHA is a dual function small molecule as both a tubulin polymerization and HDAC inhibitor, induces immunogenic cell death (ICD) through HDAC6 inhibition. |
| PC-22104 |
STR-V-53
HDAC inhibitor
|
STR-V-53 is a novel glycosylated, liver cancer-selective histone deacetylase (HDAC) inhibitor with IC50 of 24.3/60.1/213.43 nM for HDAC1/2/3/6, demonstrates exquisite selective cytotoxicity against human HCC cells. |
| PC-21991 |
DNMT/HDACi 15a
DNMT/HDAC inhibitor
|
DNMT/HDACi 15a is a potent, dual DNMT and HDAC inhibitor with IC50 of 57, 17 nM for HDAC1, HDAC6 respectively. |
| PC-21870 |
SP-2-225
HDAC6 inhibitor
|
SP-2-225 is a potent, selective HDAC6 inhibitor, improves antitumor immune responses and prevent tumor relapse after radiotherapy. |
| PC-21650 |
Tefinostat
HDAC inhibitor
|
Tefinostat (CHR-2845) is a monocyte/macrophage targeted pan histone deacetylase (HDAC) inhibitor, which is cleaved into the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). |
| PC-21608 |
CM-444
HDAC inhibitor
|
CM-444 is a potent histone deacetylase (HDAC) inhibitor with IC50 of 7/51/18/531 nM for HDAC1/2/3/6 respectively, also inhibits DNMT1 with IC50 of 2160 nM. |
