Chemical Structure : IHCH9033
CAS No.:
2921948-27-6
IHCH9033
Catalog No.: PC-23991Not For Human Use, Lab Use Only.
IHCH9033 is a selective, triazole-containing class I HDAC inhibitor, exhibits an increased antitumor effect in FLT3-ITD AML through effectively eliminating leukemia burden and overcoming resistance to FLT3i.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IHCH9033 is a selective, triazole-containing class I HDAC inhibitor, exhibits an increased antitumor effect in FLT3-ITD AML through effectively eliminating leukemia burden and overcoming resistance to FLT3i.
IHCH9033 selectively inhibited DNA repair in FLT3-ITD AML cells, leading to the accumulation of DNA damage that eventually resulted in cell cycle arrest and apoptosis.
IHCH9033 induced HSP90 acetylation, FLT3 ubiquitination, and proteasomal degradation of FLT3, thereby inhibiting FLT3 downstream signaling.
IHCH9033 maintained its potency in both FLT3i-resistant AML cell lines and primary-resistant patient samples, and exerted strong synergy with the FLT3i quizartinib, leading to tumor regression in FLT3-ITD/TKD AML xenografts.
Physicochemical Properties
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M.Wt
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461.91
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Formula
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C23H20ClN7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-amino-N-(4-((2-aminophenyl)carbamoyl)benzyl)-2-(2-chlorophenyl)-2H-1,2,3-triazole-4-carboxamide
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References
1. Yao M, et al. Exp Hematol Oncol. 2025 Feb 15;14(1):15.
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