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Chemical Structure : A452
Catalog No.: PC-38796Not For Human Use, Lab Use Only.
A452 is a potent and selective HDAC6 inhibitor, effectively inhibits the cell growth and viability of various cancer cell types, irrespective of p53 status.
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A452 is a potent and selective HDAC6 inhibitor, effectively inhibits the cell growth and viability of various cancer cell types, irrespective of p53 status.
A452 induced apoptosis by activated caspase 3 and PARP, increased Bak and Bax and decreased Bcl-xL.
A452 increased wild-type p53 levels by destabilizing MDM2, but decreased mutant p53 by inducing MDM2 and inhibiting Hsp90-mutant p53 complex formation.
A452 blocked HDAC6 nuclear localization, resulting in increased levels of acetylated p53 at Lys381/382.
A452 disrupted the HDAC6-Hsp90 chaperone machinery via Hsp90 acetylation and degradation.
A452 chemosensitized cancer cells to the Hsp90 inhibitor 17-AAG.
| M.Wt | 338.407 | |
| Formula | C20H22N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ryu HW, et al. Planta Med. 2015 Feb;81(3):222-7.
2. Ryu HW, et al. Cancer Lett. 2017 Apr 10;391:162-171.
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