BAS-2

Chemical Structure : BAS-2

Catalog No.: PC-26984Not For Human Use, Lab Use Only.

BAS-2 is a potent, highly selective HDAC6 inhibitor with IC50 of 760 nM (hHDAC6).

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Biological Activity

BAS-2 is a potent, highly selective HDAC6 inhibitor with IC50 of 760 nM (hHDAC6).
BAS-2 is a prodrug that is preferentially activated by hHDAC6 or N530D zHDAC6 (a humanized variant).
BAS-2 is not efficiently activated by D567N hHDAC6 or wild-type (WT) zHDAC6.
(±)-trans-BAS-2 is more active than cis-BAS-2.

Physicochemical Properties

M.Wt	283.39
Formula	C13H21N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazol-2-yl)thio)-1-morpholinoethan-1-one

References

1. Rodrigues DA, et al. Nat Commun. 2026 Jun 5. doi: 10.1038/s41467-026-73146-5.

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BAS-2

Biological Activity

Physicochemical Properties

References

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