Chemical Structure : HDAC6 inhibitor Compound 7b
CAS No.:
1222380-60-0
HDAC6 inhibitor Compound 7b
Catalog No.: PC-27052Not For Human Use, Lab Use Only.
HDAC6 inhibitor Compound 7b is a potent, selective HDAC6 inhibitor, inhibits proliferation, colony and spheroid formation as well as viability of prostate cancer cells, kills prostate cancer cells via HSP90α hyperacetylation-mediated androgen receptor protein downregulation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HDAC6 inhibitor Compound 7b is a potent, selective HDAC6 inhibitor, inhibits proliferation, colony and spheroid formation as well as viability of prostate cancer cells, kills prostate cancer cells via HSP90α hyperacetylation-mediated androgen receptor protein downregulation.
HDAC6 inhibitor Compound 7b induces BCR-ABL ubiquitination and degradation.
Imatinib-7b combination causes a synergistic anticancer effect in vitro and in vivo.
Imatinib-7b combination reduces the CML CSC population.
Physicochemical Properties
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M.Wt
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432.47
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Formula
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C23H28O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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heptane-1,7-diyl bis(4-hydroxy-3-methoxybenzoate)
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References
1. Carole Seidel, et al. Biochem Pharmacol. 2016 Jan 1:99:31-52.
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