Chemical Structure : Mesinostat
CAS No.:
Mesinostat
Catalog No.: PC-25904Not For Human Use, Lab Use Only.
Mesinostat is a potent and selective HDAC6 inhibitor with IC50 of 7.7 nM, >200-fold selective over HDAC1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Mesinostat is a potent and selective HDAC6 inhibitor with IC50 of 7.7 nM, >200-fold selective over HDAC1.
Mesinostat inhibits the growth of MDA-MB-231 cells with IC50 of 11 uM (48 h), induces α-tubulin acetylation. Mesinostat induces apoptosis in MDA-MB-231 cells.
Mesinostat significantly increases the expression of LC3II protein, promotes autophagy in human TNBC cells, induces cell cycle arrest.
Mesinostat suppresses epithelial-mesenchymal transition (EMT) in human TNBC cells, inhibits cell migration and colony formation.
Mesinostat (1-10 uM) reduces viability and stem-like properties in lymph node metastasis-derived TNBC organoids
Physicochemical Properties
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M.Wt
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412.47
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Formula
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C22H25FN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-fluoro-N-hydroxy-4- ((8-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro [4.5]decan-3yl) methyl) benzamide
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References
1. Bello I, et al. Pharmacol Res. 2025 Dec 2;222:108055.
2. Barone S, et al. Eur J Med Chem. 2025 Aug 5;292:117634.
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