Catalog No.: PC-26230Not For Human Use, Lab Use Only.
Pyroxamide is a potent inhibitor of HDAC with IC50 of 100 nM for HDAC1, causes the accumulation of acetylated core histones in murine erythroleukemia (MEL) cells.
Pyroxamide is a potent inhibitor of HDAC with IC50 of 100 nM for HDAC1, causes the accumulation of acetylated core histones in murine erythroleukemia (MEL) cells. Pyroxamide induces G1 arrest in transformed prostate and bladder cells in culture, induces apoptosis. Pyroxamide inhibits growth of the CWR22 human prostate xenograft. Pyroxamide induces growth suppression and cell death in human RMS in vitro.
Physicochemical Properties
M.Wt
265.31
Formula
C13H19N3O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N1-Hydroxy-N8-(pyridin-3-yl)octanediamide
References
1. Kutko MC, et al. Clin Cancer Res. 2003 Nov 15;9(15):5749-55.
2. Butler LM, et al. Clin Cancer Res. 2001 Apr;7(4):962-70.
