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EKZ-438

Chemical Structure : EKZ-438

CAS No.:

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EKZ-438 (EKZ438)

Catalog No.: PC-25868Not For Human Use, Lab Use Only.

EKZ-438 is a potent, selective, CNS-penetrant and orally bioavailable HDAC6 inhibitor with IC50 of 12 nM, >8,500-fold selectivity for HDAC6 versus all other HDAC6 paralogs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EKZ-438 is a potent, selective, CNS-penetrant and orally bioavailable HDAC6 inhibitor with IC50 of 12 nM, >8,500-fold selectivity for HDAC6 versus all other HDAC6 paralogs.
EKZ-438 selectively inhibits catalytic domain 2 of HDAC6 to increase α-tubulin acetylation.
EKZ-438 selectively inhibits HDAC6 and ameliorates excitotoxicity in a cellular model of ALS.
EKZ-438 improves axonal transport and motor function in a mouse model of familial ALS.
EKZ-438 reduces accumulation of cytoplasmically mislocalized TDP-43 in an autophagy-dependent manner.
EKZ-438 improves TDP-43 proteostasis and reduces neuroinflammation in a mouse model of ALS and FTD.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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