AMC-3-030

Chemical Structure : AMC-3-030

Catalog No.: PC-26251Not For Human Use, Lab Use Only.

AMC-3-030 is a potent, dual HDAC6/proteasome inhibitor with IC50 of 884 nM for HDAC6 and IC50 of 4.17 nM in cell-free 20S proteasomal chymotrypsin-like activity assay.

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Biological Activity

AMC-3-030 is a potent, dual HDAC6/proteasome inhibitor with IC50 of 884 nM for HDAC6 and IC50 of 4.17 nM in cell-free 20S proteasomal chymotrypsin-like activity assay.
AMC-3-030 is essentially inactive against HDAC1 (IC50 > 30 uM).

Physicochemical Properties

M.Wt	604.51
Formula	C32H41BN4O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(2-(((R)-3-methyl-1-((3aR,4R,6R,7aS)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)-N4-((phenylcarbamoyl)oxy)terephthalamide

References

1. Chan AM, et al. ACS Med Chem Lett. 2025 Dec 22;17(1):125-132.

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AMC-3-030

Biological Activity

Physicochemical Properties

References

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