Chemical Structure : UVI5008
CAS No.:
1071822-30-4
UVI5008
(UVI-5008)
Catalog No.: PC-26064Not For Human Use, Lab Use Only.
UVI5008 is a small molecule epigenetic modifier/modulator that inhibits histone deacetylases, sirtuins, and DNA methyltransferases, affects the death receptor (DR) pathway and reactive oxygen species (ROS) production in cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UVI5008 is a small molecule epigenetic modifier/modulator that inhibits histone deacetylases, sirtuins, and DNA methyltransferases, affects the death receptor (DR) pathway and reactive oxygen species (ROS) production in cancer cells.
UVI5008 inhibits MRSA by interfering with bacterial gyrase.
UVI5008 effectively inhibits both wild-type BTK and the C481S mutated BTK isoform, commonly associated with BTK-inhibitor resistance in CLL.
Physicochemical Properties
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M.Wt
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710.46
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Formula
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C26H26Br2N6O4S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2E,2'E)-N,N'-(disulfanediylbis(ethane-2,1-diyl))bis(3-(5-bromo-1H-indol-3-yl)-2-(hydroxyimino)propanamide)
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References
1. Franci G, et al. Sci Rep. 2018 Sep 3;8(1):13117.
2. Dell'Aversana C, et al. J Hematol Oncol. 2026 Feb 22. doi: 10.1186/s13045-026-01784-9.
3. Nebbioso A, et al.
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