Chemical Structure : VS-186B
CAS No.:
VS-186B
(VS186B)
Catalog No.: PC-26229Not For Human Use, Lab Use Only.
VS-186B is a small molecule HDAC inhibitor with IC50 of 2.5 uM, inhibits Class I and II HDACs in a dose-dependent manner.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VS-186B is a small molecule HDAC inhibitor with IC50 of 2.5 uM, inhibits Class I and II HDACs in a dose-dependent manner.
VS-186B is very cytotoxic to multiple cancer cell lines, specifically hematological cell lines like Jurkat, displays the most potency towards Jurkat with a CC50 of 2.91 uM.
VS-186B induces apoptosis through the intrinsic pathway in Jurkat cells, does not induce cell cycle arrest.
VS-186B induces apoptosis in cancer cells without significant cytotoxicity to non-cancerous lines with a similar gene expression profile to known HDAC inhibitors.
Physicochemical Properties
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M.Wt
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351.36
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Formula
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C20H17NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-hydroxy-4-((1E,3Z,6E)-3-hydroxy-7-(4-hydroxyphenyl)-5-oxohepta-1,3,6-trien-1-yl)benzamide
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References
1. Sanchez-Michael LA, et al. Int J Mol Sci. 2025 Nov 24;26(23):11354.
2. Allison Elias, et al. Mol Cancer Ther (2025) 24 (10_Supplement): C030.
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