Chemical Structure : Compound 5104434
CAS No.:
300399-36-4
Compound 5104434
Catalog No.: PC-25164Not For Human Use, Lab Use Only.
Compound 5104434 is a potent, selective activator of HDAC1, selectively activates HDAC1 without significant effects on HDAC2, HDAC3, or HDAC8.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Compound 5104434 is a potent, selective activator of HDAC1, selectively activates HDAC1 without significant effects on HDAC2, HDAC3, or HDAC8.
Compound 5104434 (2.5 uM) partially restored HDAC1 enzymatic activity, while 25 μM fully rescued activity to baseline levels measured via immunoprecipitation-enzyme assays.
Compound 5104434 provides specificity and selectivity in activating HDAC1 in human neural blastoma cell line, SH‐SY5Y.
Compound 5104434 at 30 mg/kg/day i.p. in a rat model of cerebral ischemia significantly restored HDAC1 activity in brain tissues, reduced infarct volume, neuronal apoptosis, DNA damage, and oxidative stress markers.
Physicochemical Properties
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M.Wt
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292.38
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Formula
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C17H24O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)methyl)-5,5-dimethylcyclohexane-1,3-dione
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References
1. L.-H. Tsai, et al. Activation of Histone Deacetylase 1 (HDAC1) Protects Against DNA Damage and Increases Neuronal Survival (2010), Patent W2010/011318 A2.
2. Costanzo G, et al. Eur J Med Chem. 2025 Jul 23;298:117998.
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