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MI-192

Chemical Structure : MI-192

CAS No.: 1415340-63-4

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MI-192 (MI192 )

Catalog No.: PC-24777Not For Human Use, Lab Use Only.

MI-192 is a potent, selective HDAC2 and HDAC3 inhibitor with IC50 of 30 nM and 16 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MI-192 is a potent, selective HDAC2 and HDAC3 inhibitor with IC50 of 30 nM and 16 nM, respectively.
MI-192 inhibits HDAC activity in HeLa cell nuclear extracts with IC50 of 1.5 uM.
MI-192 (0.1-0.4 uM) showed the greatest growth inhibitory effect against the leukemic cell lines.
MI-192 induced differentiation and was cytotoxic through promotion of apoptosis against the acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1.

Physicochemical Properties

M.Wt 383.45
Formula C24H21N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-Aminophenyl)-4-((4-methylene-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)benzamide

References

1. Boissinot M, et al. Leuk Res. 2012 Oct;36(10):1304-10.

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